7th SCI-RSC symposium on Proteinase Inhibitor Design (Proteinase 2011)

Topics: Biochemistry, Molecular Modeling, Medicinal Chemistry, Keywords: computational, structural biology, ion channels, GPCRs, proteins

Date: /11/12/ April 2011, Basel, Switzerland, Europe

Web Site, Contact: maggi [at] maggichurchouseevents.co.uk (Mrs. Maggi Churchouse)

  

Official Information:

This symposium will cover progress in the design and synthesis of aspartic, serine, cysteine and metallo protease inhibitors for a diverse range of target indications, while also covering a range of drug discovery activity: from ‘Molecules to Medicines.

Who should attend?

This meeting is aimed at medicinal chemists and other scientists interested in furthering their knowledge of proteases.

Topics

Inhibiting the uninhibitable: proteases in infectious disease and cancer
Structure-based design of selective, non-covalent cathepsin S inhibitors
Testing the amyloid hypothesis, from phenotypes to fragments
The HCV-protease inhibitor: Telaprevir
The design, SAR and synthesis of novel ADAM-TS4 (Aggrecanase-1) inhibitors for the treatment of osteoarthritis
Discovery of R1663 - a selective and efficacious factor Xa inhibitor
Computational strategies for lead finding and optimization in serine proteases
Target validation for proteases - the key factor for future success
Discovery of non-peptidic cathepsin K inhibitors for the treatment of osteoporosis
Discovery of Rivaroxaban (Xarelto®), a novel, oral, antithrombotic agent
Highly selective matrix metalloproteinase-13 Inhibitors for the treatment of osteoarthritis
Fragment-based drug discovery (FBDD) at Lilly and highlights of an FBDD approach to beta secretase

Students

Discounted rates will be offered to RSC and SCI student members.